- PUBLICATIONS -
21. Jabbarpoor, M.; Le, C. M.* Carbamoyl Fluorides: A Platform to Interrogate Fluoride-Enabled Reactivity. Synthesis 2025, ASAP, DOI: 10.1055/a-2557-7635.
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Featured in Bürgenstock Special Section 2024 – Future Stars in Organic Chemistry
20. McKnight, A.; Fujisato, Y. H.; Khanal, N.; Le, C. M.* Intramolecular Fluoroacylation Enabled by TrBF4-Catalyzed Fluoride Recycling. Org. Lett. 2025, 27, 1322−1326.
19. Jabbarpoor, M.; LeBlanc, J.; Chen, Z.; Cadwallader, D.; Le, C. M.* Pd-catalyzed Suzuki-type cross-coupling of 2-pyridyl carbamoyl fluorides. Chem. Commun., 2024, 60, 8700–8703.
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Featured in 2024 Emerging Investigators collection
18. McKnight, A. E.; Cadwallader, D.; Le, C.M.* Carbofluorination of π-Bonds and Related Reactions Involving Tandem C−C/C−F Bond Formation. Eur. J. Org. Chem. 2024, e202300017.
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Featured in EurJOC's #NextGenOrgChem Collection
17. Cadwallader, D.; Shevchuk, D.; Tiburcio, T. R.; Le, C.M.* Fluoride-Catalyzed Cross-Coupling of Carbamoyl Fluorides and Alkynylsilanes. Org. Lett. 2023, 25, 7369–7373.
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Highlighted in Organic Chemistry Portal
16. McKnight, A. E.; Arora, R.; Pradhan, E.; Fujisato, Y. H.; Ajayi, A. J.; Lautens, M.; Zeng, T.;* Le, C.M.* BF3-Catalyzed Intramolecular Fluorocarbamoylation of Alkynes via Halide Recycling. J. Am. Chem. Soc. 2023, 145, 11012–11018. ChemRxIV pre-print: 10.26434/chemrxiv-2022-464nx-v2
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Highlighted in Organic Chemistry Portal
15. Cadwallader, D.; Tiburcio, T. R.; Cieszynski, G. A.; Le, C.M.* Synthesis of Carbamoyl Fluorides Using a Difluorophosgene Surrogate Derived from Difluorocarbene and Pyridine N-Oxides. J. Org. Chem. 2022, 87, 11457–11468.
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2023 JOC Outstanding Publication of the Year Award (Read the ACS Axial Interview with Christine)
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Selected as an ACS Editors' Choice Article
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Among the most read recently published articles in JOC for 2022
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Highlighted in Organic Chemistry Portal
14. Le, C. M.* A hot take on glucose. Nat. Chem. 2022, 14, 476.
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Invited contribution to Nature Chemistry's In Your Element column
13. Le, C. M.* Direct installation of boron groups offers boost to medicinal chemistry. Nature 2021, 595, 652–653.
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Invited contribution to Nature News & Views column
12. Ackerman-Biegasiewicz, L. K. G.; Arias-Rotondo, D. M.; Biegasiewicz, K. F.; Elaqua, E.;* Golder, M. R.; Kayser, L. V.; Lamb, J. R.; Le, C. M.; Romero, N. A.; Wilkerson-Hill, S. M.; Williams, D. A. Organic Chemistry: A Retrosynthetic Approach to a Diverse Field. ACS Cent. Sci. 2020, 6, 1845–1850.
Prior to independent career
11. Chapman, S. J.; Swords, W. B.; Le, C. M.; Guzei, I. A.; Toste, F. D.; Yoon, T. P.* Cooperative Stereoinduction in Asymmetric Photocatalysis. J. Am. Chem. Soc. 2022, 144, 4206–4213.
10. Le, C. M.; Morra, B.* Retrosynthetic Graphic Organizers and Molecule of the Week Activities in Organic Chemistry Tutorials. J. Chem. Educ. 2019, 96, 1640–1645.
9. von Delius, M.;* Le, C. M.; Ellinger, B.; Kuzikov, M.; Gul, S.;* Dong, V. M.* Synthesis and Biological Activity of Octaketides from the Cytosporone Family. Isr. J. Chem. 2017, 57, 975–981.
8. Sperger, T.; Le, C. M.; Lautens, M.;* Schoenebeck, F.* Mechanistic Insights on the Pd-Catalyzed Addition of C–X Bonds across Alkynes – A Combined Experimental and Computational Study. Chem. Sci. 2017, 8, 2914–2922.
7. Le, C. M.; Sperger, T.; Fu, R.; Hou, X.; Lim, Y. H.; Schoenebeck, F.;* Lautens, M.* Stereoselective Synthesis of Methylene Oxindoles via Palladium(II)-Catalyzed Intramolecular Cross-Coupling of Carbamoyl Chlorides. J. Am. Chem. Soc. 2016, 138, 14441–14448.
6. Le, C. M.; Hou, X.; Sperger, T.; Schoenebeck, F.;* Lautens, M.* An Exclusively trans-Selective Chlorocarbamoylation of Alkynes Enabled by a Palladium/phosphaadamantane Catalyst. Angew. Chem. Int. Ed. 2015, 54, 15897–15900.
5. Le, C. M.; Menzies, P. J. C.; Petrone, D. A.; Lautens, M.* Synergistic Steric Effects in the Development of a Palladium-Catalyzed Alkyne Carbohalogenation: Stereodivergent Synthesis of Vinyl Halides. Angew. Chem. Int. Ed. 2015, 54, 254–257.
4. Petrone, D. A.; Le, C. M.; Newman, S. G.; Lautens, M.* Pd(0)-Catalyzed Carboiodination: Early Developments and Recent Advances. In New Trends in Cross-Coupling: Theory and Applications; 1st ed. Colacot, T. J. Ed. RCS Publishing: 2014; pp 276–321.
3. Zhang, L.; Le, C. M.; Lautens, M.* The Use of Silyl Ketene Acetals and Enol Ethers in the Catalytic Enantioselective Alkylative Ring Opening of Oxa/Aza Bicyclic Alkenes. Angew. Chem. Int. Ed. 2014, 53, 5951–5954.
2. von Delius, M.; Le, C. M.; Dong, V. M.* Rhodium-Phosphoramidite Catalyzed Alkene Hydroacylation: Mechanism and Octaketide Natural Product Synthesis. J. Am. Chem. Soc. 2012, 134, 15022–15032.
1. Martin, C. D.; Le, C. M.; Ragogna, P. J.* Remarkably Stable Chalcogen(II) Dications. J. Am. Chem. Soc. 2009, 131, 15126–15127.